After starting the season 2-0, the Arizona Cardinals have lost their last four games in a row by a combined nine points.
At 2-4, they’re facing a tough task in Week 7 with the NFC North-leading Green Bay Packers visiting State Farm Stadium. A loss before their Week 8 bye could put Arizona three games back in the win column from the NFC West leaders.
Unfortunately, they are planning to be without their starting quarterback for that contest.
Kyler Murray will miss a second game in a row with a mid-foot sprain, per NFL Network’s Ian Rapoport, and Jacoby Brissett will start in his place on Sunday.
Kyler Murray injury update
Murray injured his foot in the third quarter of the Cardinals’ Week 5 loss to the Tennessee Titans. He finished the game but missed practice leading up to the Colts game and did not start for the first time since November 2023.
Murray’s been off to a slow start in 2025. He’s averaging a career-low 192.4 passing yards per game and a career-high sack percentage of 9.04% through five games.
Arizona has not placed him on injured reserve (IR) and Murray did participate in practice this week in a limited fashion. For those reasons, he may be back on the field in Week 9 for Arizona after the bye.
Cardinals QB depth chart
Kyler Murray (injured)
Jacoby Brissett
Kedon Slovis
Brissett, a 10-year veteran, is on his sixth team in the last six seasons. He started five games for New England last season and went 1-4 in those contests.
Slovis was an undrafted free agent in the 2024 NFL Draft and signed with the Colts and Houston Texans’ practice squad last year before coming to Arizona. He’s yet to throw a pass in a regular-season NFL game.
NFC West standings
San Francisco 49ers: 4-2
Los Angeles Rams: 4-2
Seattle Seahawks: 4-2
Arizona Cardinals: 2-4