Thanksgiving Day will feature three NFL matchups, including the Chiefs versus the Cowboys.
The New England Patriots currently hold the NFL’s best record with a nine-game winning streak.
Shedeur Sanders is expected to start at quarterback again for the Cleveland Browns against the 49ers.
The Denver Broncos will look to extend their eight-game winning streak against the Washington Commanders.
The Thanksgiving holiday coincides with NFL Week 13, so let’s eat.
The New England Patriots are riding a nine-game winning streak and have the NFL’s best record. In the NFC, the Los Angeles Rams are feasting on the NFL and playing like the best squad in the league.
Thanksgiving Day features three juicy matchups. The Kansas City Chiefs and Dallas Cowboys are both coming off comeback wins. Thursday night concludes with Lamar Jackson and the Baltimore Ravens hosting Joe Burrow and the Cincinnati Bengals.
Shedeur Sanders is slated to start again for the Cleveland Browns this week versus the San Francisco 49ers. On Sunday night, the Denver Broncos will put their eight-game winning streak on the line against the Washington Commanders.
Gobble up on all the action this week. USA TODAY Sports provides the early predictions for Week 13:
Odds courtesy of BetMGM.
NFL Week 13 predictions, picks
Green Bay Packers vs. Detroit Lions
Date: Thursday, Nov. 27
Time: 1 p.m. ET
Location: Ford Field, Detroit
TV: FOX
Streaming: FUBO
Spread: Lions (-2.5)
Tyler Dragon, USA TODAY: Lions 28, Packers 24
Detroit’s offensive line and defense are an issue right now. The Packers already beat the Lions and have the defense that can cause them problems. However, I believe Jahmyr Gibbs will feast on the Packers and be the difference.
Jeremy Cluff, Arizona Republic: Lions 27, Packers 24
The Packers defeated the Lions in Week 1 in Green Bay, 27-13, but this game is at Ford Field in Detroit, where the Lions are 4-1 this season. The Lions’ running game will shine and Detroit will make the NFC North race even more interesting with a close win.
Kansas City Chiefs vs. Dallas Cowboys
Date: Thursday, Nov. 27
Time: 4:30 p.m. ET
Location: AT&T Stadium, Arlington, TX
TV: CBS
Streaming: Paramount+
Spread: Chiefs (-3.5)
Tyler Dragon, USA TODAY: Chiefs 28, Cowboys 24
This might be the most-watched game in the NFL this regular season. The Cowboys are feeling good after two straight emotional wins. The Chiefs are coming off a win they absolutely had to have. Cue up the Chiefs playoff push.
Jeremy Cluff, Arizona Republic: Cowboys 30, Chiefs 27
These teams are both coming off huge wins in Week 12, perhaps even signature wins. We can’t ignore the home and away records in this one, with Dallas 3-1 at home and Kansas City 1-4 on the road. Dak Prescott will outduel Patrick Mahomes as the Cowboys upset the Chiefs.
Cincinnati Bengals vs. Baltimore Ravens
Date: Thursday, Nov. 27
Time: 8:20 p.m. ET
Location: M&T Bank Stadium, Baltimore
TV: NBC
Streaming: Peacock
Spread: Ravens (-7)
Tyler Dragon, USA TODAY: Ravens 30, Bengals 26
Well, well, well, look who is first in the AFC North after a terrible 1-5 start. The Bengals always play the Ravens tough, and Joe Burrow is expected to return. But it’s time for the Ravens to stake claim of the division.
Jeremy Cluff, Arizona Republic: Ravens 28, Bengals 20
Five straight wins have put Lamar Jackson and the Ravens atop the AFC North standings. A sixth straight win could have Baltimore sitting pretty in the division race. The Bengals will drop a fifth straight game.
Chicago Bears vs. Philadelphia Eagles
Date: Friday, Nov. 28
Time: 3 p.m. ET
Location: Lincoln Financial Field, Philadelphia
TV: None
Streaming: Prime Video
Spread: Eagles (-7)
Tyler Dragon, USA TODAY: Eagles 30, Bears 21
Ben Johnson continues to make a strong case for coach of the year. The Bears have won four in a row and lead the NFC North. The Eagles must fix their offensive lulls in a hurry. The Eagles have the talent but every player on the offensive side of the football is underperforming.
Jeremy Cluff, Arizona Republic: Eagles 24, Bears 21
This Black Friday game has the potential to be very interesting. The Bears have won four straight to move to 8-3, but the 8-3 Eagles got a huge wake-up call in their loss to the Cowboys. Philadelphia will be amped for this game and force Caleb Williams into some mistakes.
San Francisco 49ers vs. Cleveland Browns
Date: Sunday, Nov. 30
Time: 1 p.m. ET
Location: Huntington Bank Field, Cleveland
TV: CBS
Streaming: FUBO
Spread: 49ers (-6.5)
Tyler Dragon, USA TODAY: 49ers 21, Browns 18
Expect the dog pound to be excited for this one. Shedeur Sanders earned the opportunity to start again. Myles Garrett and the Browns defense will keep this game close, but the 49ers find a way to win a close one.
Jeremy Cluff, Arizona Republic: 49ers 27, Browns 13
Shedeur Sanders won his first NFL start in Week 12, but that was against the lowly Las Vegas Raiders. The 49ers have a better defense, even with all of their injuries this season, and they certainly have a much better offense. This one could get ugly.
Jacksonville Jaguars vs. Tennessee Titans
Date: Sunday, Nov. 30
Time: 1 p.m. ET
Location: Nissan Stadium, Nashville
TV: CBS
Streaming: FUBO
Spread: Jaguars (-6.5)
Tyler Dragon, USA TODAY: Jaguars 28, Titans 20
The Jaguars have won two in a row and are firmly in the playoff mix. The Titans might not win another game this season.
Jeremy Cluff, Arizona Republic: Jaguars 28, Titans 17
The 1-10 Titans haven’t won a game at Nissan Stadium this season. That will continue in Week 13 as Trevor Lawrence feasts on the Tennessee secondary.
Indianapolis Colts vs. Houston Texans
Date: Sunday, Nov. 30
Time: 1 p.m. ET
Location: Lucas Oil Stadium, Indianapolis
TV: CBS
Streaming: FUBO
Spread: Colts (-4.5)
Tyler Dragon, USA TODAY: Colts 24, Texans 21
C. J. Stroud is set to return. Will Anderson Jr. and the Texans have the top defense in the NFL. The unit is going to give the Colts fits. The Colts have lost two of their last three games. But Jonathan Taylor and company get back on track at home this week.
Jeremy Cluff, Arizona Republic: Colts 27, Texans 19
The Texans’ defense gives them a fighting chance in every game, but the Colts are a perfect 6-0 at home this season. Jonathan Taylor will find a way to break some big runs for Indianapolis.
New Orleans Saints vs. Miami Dolphins
Date: Sunday, Nov. 30
Time: 1 p.m. ET
Location: Hard Rock Stadium, Miami Gardens, FL
TV: FOX
Streaming: FUBO
Spread: Dolphins (-6)
Tyler Dragon, USA TODAY: Dolphins 26, Saints 21
The Dolphins have quietly won two straight games. They should beat a bad Saints club. Mike McDaniel is making a case to keep his job.
Jeremy Cluff, Arizona Republic: Dolphins 30, Saints 13
The Dolphins are on a two-game win streak and are coming off a bye week. If it is not a three-game win streak after this game, Miami fans will be irate. Tua Tagovailoa and the Dolphins will roll.
Atlanta Falcons vs. New York Jets
Date: Sunday, Nov. 30
Time: 1 p.m. ET
Location: MetLife Stadium, East Rutherford, NJ
TV: FOX
Streaming: FUBO
Spread: Falcons (-2.5)
Tyler Dragon, USA TODAY: Falcons 24, Jets 20
Kirk Cousins deserves credit for helping the Falcons end their five-game losing streak. Bijan Robinson is third in the NFL in yards from scrimmage. Atlanta wins its second game in a row.
Jeremy Cluff, Arizona Republic: Falcons 24, Jets 21
The Falcons ended a five-game losing streak in Week 12. They’ll start a win streak in Week 13 with Bijan Robinson and Tyler Allgeier running all over New York on the road.
Arizona Cardinals vs. Tampa Bay Buccaneers
Date: Sunday, Nov. 30
Time: 1 p.m. ET
Location: Raymond James Stadium, Tampa
TV: FOX
Streaming: FUBO
Spread: Bucs (-2.5)
Tyler Dragon, USA TODAY: Bucs 24, Cardinals 20
The Bucs have lost three straight games against three of the best teams in the NFL. The Cardinals aren’t a good football team. Tampa Bay should win even without Baker Mayfield.
Jeremy Cluff, Arizona Republic: Cardinals 27, Buccaneers 23
Baker Mayfield’s status looms large in this game. Can Teddy Bridgewater lead the Buccaneers over the Cardinals if Mayfield can’t go? This game could be very intriguing. Jacoby Brissett will lead Arizona to an upset win on the road.
Los Angeles Rams vs. Carolina Panthers
Date: Sunday, Nov. 30
Time: 1 p.m. ET
Location: Bank of America Stadium, Charlotte, NC
TV: FOX
Streaming: FUBO
Spread: Rams (-10)
Tyler Dragon, USA TODAY: Rams 28, Panthers 20
The Panthers are surprisingly a playoff contender. The Rams are a Super Bowl contender, and Matthew Stafford is playing like an MVP. The Rams are the best team in football right now.
Jeremy Cluff, Arizona Republic: Rams 31, Panthers 17
The Panthers have been a pleasant surprise, but the Rams are rolling right now, with five straight wins, perhaps the MVP favorite in Matthew Stafford, and a dominating defense. That will prove to be too much for Carolina, even at home.
Minnesota Vikings vs. Seattle Seahawks
Date: Sunday, Nov. 30
Time: 4:05 p.m. ET
Location: Lumen Field, Seattle
TV: FOX
Streaming: FUBO
Spread: Seahawks (-10)
Tyler Dragon, USA TODAY: Seahawks 28, Vikings 17
Minnesota has a quarterback problem. J.J. McCarthy doesn’t look like the answer for the Vikings. Sam Darnold is going to make the Vikings regret letting him walk.
Jeremy Cluff, Arizona Republic: Seahawks 31, Vikings 15
J.J. McCarthy has struggled for the Vikings during the team’s 3-game skid. Those struggles will continue against the Seahawks and the 12th Man.
Buffalo Bills vs. Pittsburgh Steelers
Date: Sunday, Nov. 30
Time: 4:25 p.m. ET
Location: Acrisure Stadium, Pittsburgh
TV: CBS
Streaming: FUBO
Spread: Bills (-3.5)
Tyler Dragon, USA TODAY: Bills 28, Steelers 22
Aaron Rodgers should be back, but it won’t matter against Buffalo. The Steelers have lost their lead in the AFC North.
Jeremy Cluff, Arizona Republic: Bills 24, Steelers 23
This is a must-win game for both teams after they suffered rough losses in Week 12. Josh Allen’s running ability will help the Bills bounce back with a close win on the road.
Las Vegas Raiders vs. Los Angeles Chargers
Date: Sunday, Nov. 30
Time: 4:25 p.m. ET
Location: SoFi Stadium, Inglewood, CA
TV: CBS
Streaming: FUBO
Spread: Chargers (-9.5)
Tyler Dragon, USA TODAY: Chargers 23, Raiders 17
The Raiders might be playing the worst football in the NFL right now. The Chargers are coming off a bye. That should bode well for Los Angeles as they attempt to make a playoff push.
Jeremy Cluff, Arizona Republic: Chargers 24, Raiders 16
The Raiders fired offensive coordinator Chip Kelly after their fifth straight loss, but Las Vegas’ issues run a lot deeper. Jim Harbaugh will top Pete Carroll in this matchup of former Pac-12 coaching rivals.
Denver Broncos vs. Washington Commanders
Date: Sunday, Nov. 30
Time: 8:20 p.m. ET
Location: Northwest Stadium, Landover, MD
TV: NBC
Streaming: Peacock
Spread: Broncos (-6.5)
Tyler Dragon, USA TODAY: Broncos 25, Commanders 17
This game should’ve been flexed. The Broncos are fresh coming off a bye. The Commanders have lost six games in a row. It’s going to be seven straight losses for Washington this week.
Jeremy Cluff, Arizona Republic: Broncos 27, Commanders 17
The Broncos have won eight straight. The Commanders have lost six straight. Those streaks will continue. Denver’s defense will shine vs. Marcus Mariota.
New York Giants vs. New England Patriots
Date: Monday, Dec. 1
Time: 8:15 p.m. ET
Location: Gillette Stadium, Foxborough, MA
TV: ESPN
Streaming: FUBO
Spread: Broncos (-7.5)
Tyler Dragon, USA TODAY: Patriots 30, Giants 20
The Patriots enter Week 13 as the NFL’s lone 10-win team. The Giants fired their defensive coordinator a few weeks after firing their head coach. That’s how things are going in New York right about now.
Jeremy Cluff, Arizona Republic: Patriots 24, Giants 21
Can the Patriots extend their win streak to 10 games? Yes, they can. Drake Maye will shine as New England continues its surprise season with a win over the Giants.
Follow USA TODAY Sports’ Tyler Dragon on X @TheTylerDragon.